Alleviative Effect of Herbal Extract Containing Phytoconstituents of Bambusa vulgaris and Opuntia ficus-indica against AOM/DSS-Induced Colorectal-Carcinoma-Bearing Mice

Abstract The study includes preliminary phytochemical screening and assessing alleviative effects of ethanolic extract Bambusa vulgaris shoots Opuntia ficus-indica fruits (EEBO) on azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal cancer in rodents. Acute oral toxicity was performed to find the therapeutic dose EEBO. In animals, induced by single injection AOM 10 mg/kg intraperitoneally followed supply three repeated cycles 2.5% DSS solution. Then animals were treated with EEBO from third day experiment treatment continued throughout experimental period. anticancer effect assessed studying body weight (b. wt) changes, macroanatomy, antioxidant level, microanatomy colon. evaluation revealed presence alkaloid, glycoside, carbohydrate, flavonoid bamboo extract, whereas glycoside cactus extract. results found that increases b. wt level antioxidants like dismutase, glutathione, catalase meanwhile decreases malondialdehyde. Macroanatomy indicated a decrease numbers adenoma inflammatory signs group when compared diseased group. Histopathology improved colon histoarchitecture similar normal masked crypt appearance. Decreased chromosomal aberrations micronucleus observed Overall, suggest 400 exhibited highest activity 200 100 may be attributed its antigenotoxic or effect.